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https://er.knutd.edu.ua/handle/123456789/17046| Title: | Полімерна система доставки активного фармацевтичного інгредієнта флавоноїдної природи |
| Other Titles: | Polymer system for delivery of active pharmaceutical ingredient of flavonoid nature |
| Authors: | Бессарабов, В. І. Кузьміна, Г. І. Вахітова, Л. М. Баула, О. П. Василенко, В. Лісовий, В. М. Ладан, О. |
| Issue Date: | 2020 |
| Publisher: | Kyiv National University of Technology and Design |
| Citation: | Полімерна система доставки активного фармацевтичного інгредієнта флавоноїдної природи / В. Бессарабов, Г. І. Кузьміна, Л. М. Вахітова, О. Баула, В. Василенко, В. Лісовий, О. Ладан // Advanced Polymer Materials and Technologies : conference proceedings of the III International scientific conference, dedicated to the 90th anniversary of KNUTD, Kyiv, 14-15 April 2020 / red.: V. P. Plavan, I. O. Liashok, M. K. Koliada. – Kyiv : KNUTD, 2020. – P. 101-103. |
| Abstract: | Proposed method of increasing the solubility in polar solvents and, accordingly, the bioavailability of the sparingly soluble model flavonoid hesperidin by including in the composition of polymeric solid dispersed systems (SDS) in the form of a highly dispersed solid phase with the formation of intermolecular complexes of variable composition with carrier material. The dependence of flavonoid solubility on the composition of SDS was investigated. Urea, polyethylene glycol of various molecular weight, polyvinyl alcohol, propylene glycol, mannitol were used as carriers for the production of SDS. It is shown that the maximum value of the increase in solubility is observed in the system with urea in 25.1 times. |
| URI: | https://er.knutd.edu.ua/handle/123456789/17046 |
| Appears in Collections: | Наукові публікації (статті) Кафедра промислової фармації (ПФ) Advanced Polymer Materials and Technologies |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| APMT_2020_P101-103.pdf | 315,54 kB | Adobe PDF | View/Open |
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