Please use this identifier to cite or link to this item: https://er.knutd.edu.ua/handle/123456789/15945
Title: The hesperidin inhibits the butyrylcholinesterase from serum of human
Authors: Bessarabov, V. I.
Kuzmina, G. I.
Shelihatska, O. V.
Vasilev, V. I.
Saliy, O. O.
Horiushyn, I. A.
Zderko, N. P.
Keywords: hesperidin
pharmacological effect
kinetic study
Issue Date: Jun-2017
Publisher: Taras Shevchenko National University of Kyiv
Citation: The hesperidin inhibits the butyrylcholinesterase from serum of human / V. I. Bessarabov, G. I. Kuzmina, O. V. Shelihatska, V. I. Vasilev, O. O. Saliy, I. A. Horiushun, N. P. Zderko // IX-th International chemistry conference "Kyiv-Toulouse" dedicated to the 100-th anniversary of Fedir Babichev : materials of reports and performances (Kyiv, 4-9 june 2017). – Kyiv : TSNUK, 2017. – P. 127.
Abstract: Hesperidin shows a variety of pharmacological effects and is potentially promising for the treatment of neurodegenerative diseases. Literature review and in-house QSAR analysis showed that hesperidin also displays the various biological and pharmacological properties, including antiinflammatory, antineoplastic, antidepressant and antioxidant activity. Molecular docking of hesperidin into the active site of BChE allows to assume the existence of the inhibition effect. Hesperidin inhibits the BChE by mixed mechanism. Further comprehensive research in this area is relevant with aim of further development of drugs for the treatment of neurodegenerative diseases.
URI: https://er.knutd.edu.ua/handle/123456789/15945
Faculty: Факультет хімічних та біофармацевтичних технологій
Department: Кафедра промислової фармації
Appears in Collections:Кафедра промислової фармації (ПФ)
Матеріали наукових конференцій та семінарів

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